I-PROFEN suspension<\/p>\n
Active ingredients: Each 5 ml contain:
\nIbuprofen 100 mg<\/p>\n
Mode of Action:
\nI-PROFEN suspension contains ibuprofen which is a propionic acid class of NSAIDs with analgesic, anti-inflammatory and anti-pyretic activity through its inhibitory effect on the enzyme cyclo-oxygenase, which results in a marked reduction in prostaglandin synthesis.<\/p>\n
Indications:
\n\u2022 Rheumatoid arthritis (including juvenile rheumatoid arthritis or Still\u2019s disease), ankylosing spondylitis, osteoarthritis and other non-rheumatoid (seronegative) arthropathies.
\n\u2022 Non-articular rheumatic conditions, I-Profen Suspension is indicated in peri-articular conditions such as frozen shoulder (capsulitis), bursitis, tendinitis, tenosynovitis and low back pain; I-Profen Suspension can also be used in soft-tissue injuries such as sprains and strains.
\n\u2022 Mild to moderate pain such as dysmenorrhea, dental and post-operative pain and for symptomatic relief of headache including migraine headache.
\n\u2022 Short-term use for the treatment of pyrexia in children over one year of age.<\/p>\n
Posology:
\nAdults and children >12 years of age: The recommended daily dosage is 1200-1800 mg in divided doses. Total daily dose should not exceed 2400 mg.
\nChildren: The recommended daily dosage is 20-40 mg\/kg in divided doses.<\/p>\n
Precautions:
\n\u2022 Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms.
\n\u2022 To be taken preferably with or after food.<\/p>\n
Contraindications:
\n\u2022 Hypersensitivity to the active substance, any of the excipients, or other NSAIDs.
\n\u2022 Children < 7 kg.
\n\u2022 Active or history of peptic ulcer, perforation or gastrointestinal bleeding (\u22652 episodes).
\n\u2022 Bleeding tendency
\n\u2022 Severe heart failure (NYHA Class IV), hepatic failure and renal failure
\n\u2022 Pregnancy (contraindicated in last trimester; use upon doctor\u2019s advice in the 1st and 2nd trimesters) and breastfeeding.
\n\u2022 Rare hereditary problems of fructose intolerance or glucose-galactose malabsorption.<\/p>\n
Undesirable effects:
\nCommon adverse events (\u22651\/100 to <1\/10) include headache, dizziness, dyspepsia, diarrhea, nausea, vomiting, abdominal pain, flatulence, constipation, melaena, hematemesis, gastrointestinal hemorrhage, rash, and fatigue.<\/p>\n
Pharmacokinetic properties:
\n\u2022 Ibuprofen is rapidly absorbed from the gastrointestinal tract, peak serum concentrations occurring 1-2 hours after administration. The elimination half-life is approximately 2 hours.
\n\u2022 Ibuprofen is metabolized in the liver to two inactive metabolites and these, together with unchanged ibuprofen, are excreted by the kidney either as such or as conjugates. Excretion by the kidney is both rapid and complete.
\n\u2022 Ibuprofen is extensively bound to plasma proteins.<\/p>\n
Storage and disposal:
\n\u2022 Keep in a safe place, out of reach and sight of children.
\n\u2022 Store below 25\u00b0 C. Protect from light.<\/p>\n","protected":false},"excerpt":{"rendered":"
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