Loraday syrup<\/p>\n
Active ingredients: Each 5 ml contains:
\nLoratadine 5 mg<\/p>\n
Mode of Action:
\nLORADAY is a non-sedating antihistamine with selective peripheral H1-receptor antagonistic activity and does not have sedative effects at the recommended dose.<\/p>\n
Indications:
\nLORADAY is used for the relief of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria in adults and children over the age of 2 years.<\/p>\n
Posology:
\nAdults and children \u2265 12 years: 10 ml (10 mg) of the syrup, once daily
\nChildren 2 to 11 years:
\n\u2022 Body weight > 30 kg: 10 ml (10 mg) of the syrup, once daily
\n\u2022 Body weight \u2264 30 kg: 5 ml (5 mg) of the syrup, once daily.<\/p>\n
Precautions:
\n\u2022 Safety and efficacy of Loratadine in children under 2 years of age have not been established.
\n\u2022 Used with caution in patients with severe hepatic impairment.
\n\u2022 Loraday syrup should be discontinued at least 48 hours before skin tests since antihistamines may prevent or reduce otherwise positive reactions to dermal reactivity index.<\/p>\n
Contraindications:
\n\u2022 Hypersensitivity to the active substance or any of the excipients.
\n\u2022 Pregnancy and breastfeeding.
\n\u2022 Rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase isomaltase insufficiency.<\/p>\n
Undesirable effects:
\nIn clinical trials involving adults and adolescents, the most frequent adverse reactions reported in excess of placebo were somnolence (1.2%), headache (0.6%), increased appetite (0.5%) and insomnia (0.1%). In clinical trials in a pediatric population, common adverse reactions reported in excess of placebo were headache (2.7%), nervousness (2.3%), and fatigue (1%).<\/p>\n
Pharmacokinetic properties:
\n\u2022 Loratadine is rapidly and well-absorbed. Concomitant ingestion of food can delay slightly the absorption of loratadine but without influencing the clinical effect. The bioavailability parameters of loratadine and of the active metabolite are dose proportional.
\n\u2022 Loratadine is highly bound (97% to 99%) and its active metabolite moderately bound (73% to 76%) to plasma proteins.
\n\u2022 After oral administration, loratadine is rapidly and well absorbed and undergoes an extensive first pass metabolism, mainly by CYP3A4 and CYP2D6.
\n\u2022 Approximately 40% of the dose is excreted in the urine and 42% in the feces over a 10-day period and mainly in the form of conjugated metabolites. Approximately 27% of the dose is eliminated in the urine during the first 24 hours. Less than 1% of the active substance is excreted unchanged in active form, as loratadine or DL. The mean elimination half-lives in healthy adult subjects were 8.4 hours (range = 3 to 20 hours) for loratadine and 28 hours (range = 8.8 to 92 hours) for the major active metabolite.<\/p>\n
Storage and disposal:
\n\u2022 Keep in a safe place, out of reach and sight of children.
\n\u2022 Store below 30\u00b0 C.<\/p>\n","protected":false},"excerpt":{"rendered":"
Loraday Syrup contains 5 mg loratadine per 5 ml, a non-sedating antihistamine for relief of symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria. For adults and children \u226512 years: 10 ml once daily; children 2\u201311 years: 5\u201310 ml once daily, based on body weight. Not for children under 2 years.<\/p>\n","protected":false},"featured_media":188127,"template":"","meta":{"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"product_cat":[20713,23348,23374],"product_tag":[20997,20985,11798,20998,3127,20987,20969,20983,20986],"class_list":["post-28804","product","type-product","status-publish","has-post-thumbnail","product_cat-allergy-cold-cough","product_cat-under-3kd","product_cat-under-5kd","product_tag-and-sneezing-how-to-use-once-daily-before-sleep-or-as-prescribed","product_tag-and-the-common-cold-these-symptoms-include-rash","product_tag-cough","product_tag-hay-fever-2","product_tag-itching","product_tag-itchy-eyes-nose-throat","product_tag-runny-nose","product_tag-used-to-treat-symptoms-of-allergy","product_tag-watery-eyes","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product\/28804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/media\/188127"}],"wp:attachment":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/media?parent=28804"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product_cat?post=28804"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product_tag?post=28804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}