Fludrex tablets<\/p>\n
Active ingredients: Each tablet contains:
\nParacetamol 400 mg
\nPseudoephedrine HCl 30 mg,
\nCaffeine anhydrous 32 mg
\nChlorpheniramine maleate 3 mg.<\/p>\n
Mode of Action:
\nParacetamol: based on the inhibition of prostaglandin biosynthesis.
\nPseudoephedrine: has direct and indirect sympathomimetic activity and is an effective upper respiratory decongestant.
\nChlorphenamine maleate: potent antihistamine (H1-antagonist).
\nCaffeine: Caffeine is a central nervous system stimulant.<\/p>\n
Indications:
\nFLUDREX is particularly effective against the symptoms of cold and flu.
\n\u2022 Relieving nasal congestion and rhinorrhea.
\n\u2022 Lowering temperature due to common cold & flu.
\n\u2022 Relieving pain and headache.<\/p>\n
Posology:
\nAdults and children \u2265 12 years: one tablet 3 times daily (every 8 hours)<\/p>\n
Precautions:
\n\u2022 Do not exceed the stated dose. Maximum dose 8 tablets in 24 hours.
\n\u2022 Caution when used in children from 6-12 years, patients with diabetes, hypertension, hyperthyroidism and ischemic heart disease, in case of epilepsy, prostatic hypertrophy, urinary retention, glaucoma and hepatic diseases, and in patients with a history of peptic ulcer.<\/p>\n
Contraindications:
\n\u2022 Hypersensitivity to any component of Fludrex preparations.
\n\u2022 Children <6 years.
\n\u2022 Pregnancy (unless prescribed) and breastfeeding.
\n\u2022 In combination with Monoamine Oxidase Inhibitors (MAOIs).<\/p>\n
Undesirable effects:
\nThe following side effects may occur during the treatment: somnolence, insomnia, dizziness, allergic skin rashes, palpitations and gastrointestinal disturbances.<\/p>\n
Pharmacokinetic properties:
\n\u2022 ABSORPTION: Paracetamol: is rapidly and almost completely absorbed from the gastrointestinal tract. Pseudoephedrine: the C max of pseudoephedrine was approximately 180 ng\/ml with t-max occurring at approximately 1.5 hours for the tablets after drug administration. Chlorphenamine maleate is well absorbed from the gastro-intestinal tract, following oral administration. The effects develop within 30 minutes, are maximal within 1 to 2 hours and last 4 to 6 hours. The plasma half-life has been estimated to be 12 to 15 hours. Caffeine is absorbed readily after oral administration, but absorption from the gastrointestinal tract may be erratic. There is little evidence of accumulation in any tissue. Caffeine passes readily into the central nervous system and into saliva. Concentrations have also been detected in breast milk.
\n\u2022 DISTRIBUTION: The apparent volume of distribution of pseudoephedrine (Vd\/F) was approximately 2.8 l\/kg.
\n\u2022 METABOLISM AND ELIMINATION: Paracetamol: The concentration in plasma reaches a peak in 30 to 60 minutes and the plasma half-life is 1 \u2013 4 hours after therapeutic doses. Paracetamol is relatively uniformly distributed throughout most body fluids. Plasma Protein Binding of the drug is variable; 20 to 30% may be bound at the concentrations encountered during acute intoxication. Pseudoephedrine: the t\u00bd was approximately 5.5 hours. Pseudoephedrine is partly metabolized in the liver by N-demethylation to nor-pseudoephedrine, an active metabolite. Pseudoephedrine and its metabolite are excreted in the urine; 55% to 90% of a dose is excreted unchanged. Chlorphenamine: is metabolized to monodesmethyl and didesmethyl derivatives. About 22% of an oral dose is excreted unchanged in the urine. Caffeine: It is metabolized almost completely and is excreted in the urine as 1-methyluric acid, 1-methylxanthine and other metabolites, with only about 1% unchanged.<\/p>\n
Storage and disposal:
\n\u2022 Keep in a safe place, out of the reach and sight of children.
\n\u2022 Store below 25 \u00baC, Protect from light.<\/p>\n","protected":false},"excerpt":{"rendered":"
Fludrex Tablets combine paracetamol (400 mg), pseudoephedrine (30 mg), caffeine (32 mg), and chlorpheniramine maleate (3 mg) to relieve cold and flu symptoms, including nasal congestion, fever, headache, and pain. Suitable for adults and children aged 12 years or older, with a dosage of one tablet every 8 hours.<\/p>\n","protected":false},"featured_media":188144,"template":"","meta":{"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"product_cat":[20713,23348],"product_tag":[20975,20974,21107,421,20978,20976,20972,20979,20980,20977,20973],"class_list":["post-28790","product","type-product","status-publish","has-post-thumbnail","product_cat-allergy-cold-cough","product_cat-under-3kd","product_tag-and-other-symptoms-e-g","product_tag-body-aches","product_tag-bronchitis-how-to-use-two-tablets-twice-daily-after-meals-or-as-prescribed","product_tag-fever","product_tag-flu","product_tag-headache","product_tag-is-used-to-temporarily-treat-cough","product_tag-or-other-breathing-illnesses-e-g","product_tag-sinusitis","product_tag-sore-throat-caused-by-the-common-cold","product_tag-stuffy-nose","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product\/28790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/media\/188144"}],"wp:attachment":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/media?parent=28790"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product_cat?post=28790"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product_tag?post=28790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}