Fludrex syrup<\/p>\n
Active ingredients: Each 5 ml contain:
\nParacetamol 120 mg
\nPseudoephedrine HCl 15 mg
\nChlorpheniramine maleate 0.75 mg<\/p>\n
Mode of Action:
\nParacetamol: based on the inhibition of prostaglandin biosynthesis.
\nPseudoephedrine: has direct and indirect sympathomimetic activity and is an effective upper respiratory decongestant.
\nChlorphenamine maleate: potent antihistamine (H1-antagonist).<\/p>\n
Indications:
\nFLUDREX is particularly effective against the symptoms of cold and flu.
\n\u2022 Relieving nasal congestion and rhinorrhea.
\n\u2022 Lowering temperature due to common cold & flu.
\n\u2022 Relieving pain and headache.<\/p>\n
Posology:
\nChildren 6-12 years: Two teaspoonful (10 ml), 3 times daily (every 8 hours).<\/p>\n
Precautions:
\n\u2022 Do not exceed the stated dose.
\n\u2022 Caution when used in children from 6-12 years, patients with diabetes, hypertension, hyperthyroidism and ischemic heart disease, in case of epilepsy, prostatic hypertrophy, urinary retention, glaucoma and hepatic diseases.<\/p>\n
Contraindications:
\n\u2022 Hypersensitivity to any component of Fludrex preparations.
\n\u2022 Children <6 years.
\n\u2022 Pregnancy (unless prescribed) and breastfeeding.
\n\u2022 In combination with Monoamine Oxidase Inhibitors (MAOIs).<\/p>\n
Undesirable effects:
\nThe following side effects may occur during the treatment: somnolence, insomnia, dizziness, allergic skin rashes, palpitations and gastrointestinal disturbances.<\/p>\n
Pharmacokinetic properties:
\n\u2022 ABSORPTION: Paracetamol: is rapidly and almost completely absorbed from the gastrointestinal tract. Pseudoephedrine: the C max of pseudoephedrine was approximately 180 ng\/ml with t-max occurring at approximately 1.5 hours for the tablets after drug administration. Chlorphenamine maleate is well absorbed from the gastro-intestinal tract, following oral administration. The effects develop within 30 minutes, are maximal within 1 to 2 hours and last 4 to 6 hours. The plasma half-life has been estimated to be 12 to 15 hours.
\n\u2022 DISTRIBUTION: The apparent volume of distribution of pseudoephedrine (Vd\/F) was approximately 2.8 l\/kg.
\n\u2022 METABOLISM AND ELIMINATION: Paracetamol: The concentration in plasma reaches a peak in 30 to 60 minutes and the plasma half-life is 1 \u2013 4 hours after therapeutic doses. Paracetamol is relatively uniformly distributed throughout most body fluids. Plasma Protein Binding of the drug is variable; 20 to 30% may be bound at the concentrations encountered during acute intoxication. Pseudoephedrine: the t\u00bd was approximately 5.5 hours. Pseudoephedrine is partly metabolized in the liver by N-demethylation to nor-pseudoephedrine, an active metabolite. Pseudoephedrine and its metabolite are excreted in the urine; 55% to 90% of a dose is excreted unchanged. Chlorphenamine: is metabolized to monodesmethyl and didesmethyl derivatives. About 22% of an oral dose is excreted unchanged in the urine.<\/p>\n
Storage and disposal:
\n\u2022 Keep in a safe place, out of the reach and sight of children.
\n\u2022 Store below 30 \u00baC, Protect from light.<\/p>\n","protected":false},"excerpt":{"rendered":"
Fludrex Syrup contains paracetamol (120 mg), pseudoephedrine (15 mg), and chlorpheniramine maleate (0.75 mg) per 5 ml. It relieves cold and flu symptoms including nasal congestion, fever, pain, and headache. Recommended for children 6-12 years: 10 ml three times daily, with precautions for certain medical conditions.<\/p>\n","protected":false},"featured_media":188142,"template":"","meta":{"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"product_cat":[20713,23348],"product_tag":[20975,20974,20981,421,20978,20976,20972,20979,20980,20977,20973],"class_list":["post-28693","product","type-product","status-publish","has-post-thumbnail","product_cat-allergy-cold-cough","product_cat-under-3kd","product_tag-and-other-symptoms-e-g","product_tag-body-aches","product_tag-bronchitis-how-to-use-twice-to-three-times-daily","product_tag-fever","product_tag-flu","product_tag-headache","product_tag-is-used-to-temporarily-treat-cough","product_tag-or-other-breathing-illnesses-e-g","product_tag-sinusitis","product_tag-sore-throat-caused-by-the-common-cold","product_tag-stuffy-nose","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product\/28693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/media\/188142"}],"wp:attachment":[{"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/media?parent=28693"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product_cat?post=28693"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/targetphkw.com\/ar\/wp-json\/wp\/v2\/product_tag?post=28693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}